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  • Title: Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway.
    Author: Zeng CC, Zhang C, Yao JH, Lai SH, Han BJ, Li W, Tang B, Wan D, Liu YJ.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2016 Nov 05; 168():199-205. PubMed ID: 27294548.
    Abstract:
    In this article, the in vitro cytotoxicity of platycodin D was evaluated in human PC-12, SGC-7901, BEL-7402, HeLa and A549 cancer cell lines. PC-12 cells were sensitive to platycodin D treatment, with an IC50 value of 13.5±1.2μM. Morphological and comet assays showed that platycodin D effectively induced apoptosis in PC-12 cells. Platycodin D increased the levels of reactive oxygen species (ROS) and induced a decrease in mitochondrial membrane potential. Platycodin D induced cell cycle arrest at the G0/G1 phase in the PC-12 cell line. Platycodin D can induce autophagy. In addition, platycodin D can down-regulate the expression of Bcl-2 and Bcl-x, and up-regulate the levels of Bid protein in the PC-12 cells. The results demonstrated that platycodin D induced PC-12 cell apoptosis through a ROS-mediated mitochondrial dysfunction pathway.
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