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  • Title: Structure-activity relationships for the direct toxic action of trichothecenes on rat brain.
    Author: Bergmann F, Yagen B.
    Journal: Arch Toxicol; 1989; 63(2):155-6. PubMed ID: 2730341.
    Abstract:
    Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3 alpha-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8 alpha-hydroxy group enhances toxicity about 4-fold.
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