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  • Title: Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.
    Author: Lumb M, Deacon R, Perry J, Chanarin I.
    Journal: Biochem J; 1989 Mar 15; 258(3):907-10. PubMed ID: 2730574.
    Abstract:
    Rats were exposed to nitrous oxide, which inactivates cob(I)alamin (Cbl). As in air-breathing rats methionine administration led to the conversion of hepatic 5-methyltetrahydrofolate (MeH4 folate) into formyltetrahydrofolate. The recovery of MeH4 folate levels in liver after its oxidation initiated by methionine was noted and the rate compared with that for air-breathing rats. Oxidation of MeH4 folate was less complete and occurred more slowly in Cbl-inactivated rats as compared with controls. However, recovery of MeH4 folate levels was more rapid in Cbl inactivation. S-Adenosylmethionine did not produce a significant change in MeH4 folate levels in Cbl-inactivated rats, whereas it did so in air-breathing animals.
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