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  • Title: Characterization of ribonucleolytic activity of angiogenin towards tRNA.
    Author: Lee FS, Vallee BL.
    Journal: Biochem Biophys Res Commun; 1989 May 30; 161(1):121-6. PubMed ID: 2730651.
    Abstract:
    Yeast tRNA is a convenient substrate for the assay of the ribonucleolytic activity of human angiogenin. The optimal pH, [NaCl], and temperature for tRNA cleavage by angiogenin are approximately 6.8, 15-30 mM, and approximately 55 degrees C, respectively, as compared with approximately 8.0, 100-200 mM, and approximately 65 degrees C, respectively, for RNase A. Polyanions and metals both inhibit angiogenin and RNase A but to different extents.
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