These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Acetylcholine-induced inhibition in the cat visual cortex is mediated by a GABAergic mechanism.
    Author: Müller CM, Singer W.
    Journal: Brain Res; 1989 May 22; 487(2):335-42. PubMed ID: 2731048.
    Abstract:
    The influence of iontophoretically applied acetylcholine (ACh) on single-unit activity in the visual cortex was studied in anesthetized cats. The dominant effect consisted of a slow facilitation of neuronal responses to moving light bars. This cholinergic action was sometimes paralleled by a decrease of the cells' selectivity to the direction of stimulus movement. In about one-third of the neurons studied ACh-iontophoresis suppressed maintained and visually driven activity within a few hundred milliseconds from the onset of its application. This effect was antagonized by concurrent iontophoresis of the muscarinic ACh-receptor antagonist scopolamine and the GABAA-receptor antagonist bicuculline methiodide. In 7% of the units studied a fast excitation was elicited by ACh application showing a similar time course as the rapid suppressive effect. It is concluded that ACh-induced inhibition is mediated by an activation of GABAergic interneurons. The role of cholinergic depression and facilitation in cortical information processing is discussed.
    [Abstract] [Full Text] [Related] [New Search]