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  • Title: [Clinical evaluation and comparison of the effects of Dobuject and Dobutrex after open heart surgery].
    Author: Vojtísková J, Vránová Z, Uhlír O, Skibová J.
    Journal: Cas Lek Cesk; 1989 Mar 31; 128(14):433-7. PubMed ID: 2731212.
    Abstract:
    The paper list the results of a comparative study on the clinical and haemodynamic effects of 2 medicaments, registered in the Czechoslovak Socialist Republic, i. e. dobutamine hydrochloride, Dobutrex the Federal Republic of Germany) and Dobuject (Loiras, Finland). The medicaments were applied to high-risk patients (NYHA III-IV) after open heart surgery with the low cardiac output syndrome. Dobutrex was applied in 14 patients and Dobuject in 16 patients. Both preparations improved the cardiac output shown in an increased cardiac index and left ventricular stroke work index and the pressure decrease in pulmonary capillaries measured with a wedged-in catheter. Both these preparations (Dobutrex, Dobuject) appear to have comparable parameters as regards favourable positive inotropic effects.
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