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  • Title: [Intraperitoneal administration of high doses of cisplatin in advanced ovarian carcinoma].
    Author: Ptácková B, Kopecný J, Zatocil P, Anton M.
    Journal: Cesk Gynekol; 1989 Mar; 54(2):106-9. PubMed ID: 2731237.
    Abstract:
    42 patients with advanced ovarian carcinoma were treated with large doses of cis-DDP by the i.p. route. The toxic effects of platinum were reduced by the i.v. administration of thisulphate. Depending on age and the general condition of the patient, 200-270 mg cis-DDP were administered in one series. Ascites disappeared in 54.7% patients, partial remission of the tumour was achieved in 28.5%, complete histopathological remission confirmed by second look operation in 26.2% and in 21.4% the result was doubtful.
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