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  • Title: The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma.
    Author: Gujar AD, Yano H, Kim AH.
    Journal: Mol Cell Oncol; 2016 May; 3(3):e1075644. PubMed ID: 27314081.
    Abstract:
    Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20-anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.
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