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  • Title: Effects of cadmium exposure on glycogen phosphorylase activity in rat placenta as demonstrated by histochemical means.
    Author: Hazelhoff Roelfzema W, Hacker HJ, Van Noorden CJ.
    Journal: Histochemistry; 1989; 91(4):305-8. PubMed ID: 2732094.
    Abstract:
    Glycogen phosphorylase (PHO) activity was demonstrated histochemically in unfixed cryostat sections of placentae from cadmium-treated and control rats with the use of the semipermeable membrane technique. Staining of the newly synthesized glycogen was performed by lugol. A high activity was present in glycogen cells, spongiotrophoblast and visceral yolk sac from cadmium-treated and control animals. A low but distinct activity could be demonstrated in placental labyrinth from control rats in late pregnancy. Cadmium-exposed rats showed a considerably higher activity in the labyrinth during this period of pregnancy. The elevated PHO activity and concomitant higher glycogen content indicate a disturbance by exposure to cadmium of placental carbohydrate metabolism from day 18 onwards.
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