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  • Title: In-vitro activity of PD 117558, a new quinolone against bacterial isolates from cancer patients.
    Author: Rolston KV, LeBlanc B, Gooch G, Ho DH, Bodey GP.
    Journal: J Antimicrob Chemother; 1989 Mar; 23(3):363-71. PubMed ID: 2732120.
    Abstract:
    The in-vitro activity of PD 117558, a new quinolone antimicrobial agent, was compared to that of four other quinolones, imipenem and ceftazidime against a variety of Gram-positive and Gram-negative isolates from cancer patients. PD 117558 was found to have a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus faecalis and Group JK-corynebacteria). It was also extremely active against Gram-negative bacilli with the exception of Pseudomonas aeruginosa against which ciprofloxacin was more active. Fleroxacin was slightly less active and S-25930 and S-25932 considerably less active than PD 117558. PD 117558 also had lower minimal inhibitory concentrations for most organisms tested than either imipenem or ceftazidime.
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