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  • Title: Lithium alters the stereoselectivity of monoamine oxidase in rat brain.
    Author: Smith DF.
    Journal: J Neural Transm; 1989; 76(3):205-10. PubMed ID: 2732725.
    Abstract:
    The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (-)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (-)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereoselective index for MAO, which suggests that lithium altered conformational features of the enzyme.
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