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  • Title: Malignant melanoma arising in a mature teratoma: A case report with review of the recent literature.
    Author: Brudie LA, Khan F, Radi MJ, Yates MM, Ahmad S.
    Journal: Gynecol Oncol Rep; 2016 Apr; 16():47-50. PubMed ID: 27331138.
    Abstract:
    Mature cystic teratomas constitute 10-20% of all ovarian neoplasms. Malignant transformation is very rare occurring in only 0.1-2% of mature teratoma cases. Malignant melanoma is among the least common transformations. Herein, we describe a case of young woman initially undergoing evaluation for infertility who was found to have malignant melanoma arising in a mature dermoid cyst. She subsequently underwent unilateral salpingo-oophorectomy with staging procedure with benign pathology. There was no need for adjuvant therapy and the patient is without disease to date (nearly 10-months in follow-up now). We reviewed the existing literature and this is one of only a few cases documented in the last decade.
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