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  • Title: Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea.
    Author: Torres-Mendoza D, González Y, Gómez-Reyes JF, Guzmán HM, López-Perez JL, Gerwick WH, Fernandez PL, Gutiérrez M.
    Journal: Molecules; 2016 Jun 22; 21(6):. PubMed ID: 27338338.
    Abstract:
    Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.
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