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  • Title: Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period.
    Author: Jun SY, Jung GM, Yoon SJ, Youm SY, Han HY, Lee JH, Kang SH.
    Journal: Clin Exp Pharmacol Physiol; 2016 Oct; 43(10):1013-6. PubMed ID: 27341401.
    Abstract:
    SAL200 is a new phage endolysin-based candidate drug for the treatment of staphylococcal infections. An intravenous administration study was conducted in monkeys to obtain pharmacokinetic information on SAL200 and to assess the safety of a short SAL200 dosing period (<1 week). Maximum serum drug concentrations and systemic SAL200 exposure were proportional to the dose and comparable in male and female monkeys. SAL200 was well tolerated, and no adverse events or laboratory abnormalities were detected after injection of a single dose of up to 80 mg/kg per day, or injection of multiple doses of up to 40 mg/kg per day.
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