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  • Title: Generation of a human iPSC line from a patient with a defect of intergenomic communication.
    Author: Zurita F, Galera T, González-Páramos C, Moreno-Izquierdo A, Schneiderat P, Fraga MF, Fernández AF, Garesse R, Gallardo ME.
    Journal: Stem Cell Res; 2016 Jan; 16(1):120-3. PubMed ID: 27345795.
    Abstract:
    Human iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus.
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