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  • Title: Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672.
    Author: Yurchenko AN, Smetanina OF, Ivanets EV, Kalinovsky AI, Khudyakova YV, Kirichuk NN, Popov RS, Bokemeyer C, von Amsberg G, Chingizova EA, Afiyatullov SSh, Dyshlovoy SA.
    Journal: Mar Drugs; 2016 Jun 27; 14(7):. PubMed ID: 27355960.
    Abstract:
    Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spectroscopic methods. The absolute configuration of pretrichodermamide D (1) was established by a combination of modified Mosher's method, NOESY data, and biogenetic considerations. N-Methylpretrichodermamide B (5) showed strong cytotoxicity against 22Rv1 human prostate cancer cells resistant to androgen receptor targeted therapies.
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