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  • Title: Nickel-Catalyzed Reductive Amidation of Unactivated Alkyl Bromides.
    Author: Serrano E, Martin R.
    Journal: Angew Chem Int Ed Engl; 2016 Sep 05; 55(37):11207-11. PubMed ID: 27357076.
    Abstract:
    A user-friendly, nickel-catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.
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