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  • Title: Interaction of the novel agent amphethinile with tubulin.
    Author: McGown AT, Fox BW.
    Journal: Br J Cancer; 1989 Jun; 59(6):865-8. PubMed ID: 2736224.
    Abstract:
    The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (Ka = 1.3 x 10(6) M-1). It is concluded that amphethinile belongs to the class of agents which share a common binding site with colchicine on the tubulin molecule.
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