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  • Title: Positive association between CD44 gene rs13347 C>T polymorphism and risk of cancer in Asians: a systemic review and meta-analysis.
    Author: Shi J, Duan Y, Pan L, Zhou X.
    Journal: Onco Targets Ther; 2016; 9():3493-500. PubMed ID: 27366086.
    Abstract:
    BACKGROUND: Cluster of differentiation 44 (CD44) is an important surface marker of cancer stem cells in a variety of tumors. A number of previous studies have been conducted to investigate the association between CD44 gene rs13347 C>T polymorphism and cancer risk in humans; nevertheless, the results remain controversial. We therefore performed this meta-analysis to confirm the role of this polymorphism in susceptibility to human cancer. MATERIALS AND METHODS: The studies published up to December 2015 were searched in PubMed, Web of Science, and China National Knowledge Infrastructure databases. Twelve eligible case-control studies were identified, involving a total of 6,982 cases and 7,430 controls. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using a fixed or random-effect model to estimate the strength of the association. RESULTS: The results of the overall analyses indicated that CD44 gene rs13347 polymorphism was significantly associated with cancer risk in Asians (CT vs CC: OR =1.35, 95% CI =1.12-1.62; TT vs CC: OR =1.99, 95% CI =1.52-2.60; TT + CT vs CC: OR =1.41, 95% CI =1.16-1.71; and TT vs CC + CT: OR =1.74, 95% CI =1.41-2.14), especially in Chinese population (CT vs CC: OR =1.42, 95% CI =1.16-1.75; TT vs CC: OR =2.13, 95% CI =1.58-2.86; TT + CT vs CC: OR =1.50, 95% CI =1.21-1.87; and TT vs CC + CT: OR =1.80, 95% CI =1.43-2.26). In stratified analyses by cancer types, there was evidence for an association between this polymorphism and nasopharyngeal cancer and breast cancer, respectively. CONCLUSION: The results of this meta-analysis suggest that the CD44 gene rs13347 C>T polymorphism is associated with elevated risk of human cancer in Asians, especially in Chinese population. Further well-designed studies on a larger population covering other ethnicities should be carried out to validate our results.
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