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  • Title: Antitumor and immunomodulation activities of polysaccharide from Phellinus baumii.
    Author: Liu MM, Zeng P, Li XT, Shi LG.
    Journal: Int J Biol Macromol; 2016 Oct; 91():1199-205. PubMed ID: 27370747.
    Abstract:
    A homogeneous polysaccharide (PPB) was purified from fruiting bodies of Phellinus baumii. And in vitro antitumor and immunomodulation activities were investigated on HeLa, SGC-7901 and RAW264.7 cell lines. PPB inhibited the proliferation of HeLa and SGC-7901 cells significantly, and flow cytometric studies revealed that PPB could mediate the cell cycle in the G0/G1 and S phases. Furthermore, PPB could promote the growth and phagocytosis of RAW264.7 cells, activate the secretion of cytokines such as TNF-α and IL-6, which indicated that PPB had low toxicity. The results make PPB as a candidate adjuvant in cancer therapy.
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