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  • Title: [Dependence of the antitumor activity of nitroso alkyl urea derivatives on their chemical structure].
    Author: Sharashidze LK, Turkiia NG, Lagidze DR, Adamiia IK, Asatiani VV.
    Journal: Eksp Onkol; 1989; 11(2):62-5. PubMed ID: 2737133.
    Abstract:
    The antitumour activity of 10 analogs of nitroso alkyl urea was studied on 6 tumour strains. It was shown that antitumour effect depends upon the gentle structural changes of substances (changes of side chain, the position of aromatic nucleus in it, as well as the nature, quantity and position of substitutes in the nucleus). 7 compounds out of 10 analogs of nitroso alkyl urea have manifested antitumour activity.
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