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  • Title: Pyruvate kinase inhibited by L-cysteine as a marker of tumorigenic human urothelial cell lines.
    Author: Gumińska M, Stachurska MB, Christensen B, Tromholt V, Kieler J, Radzikowski C, Duś D.
    Journal: Experientia; 1989 Jun 15; 45(6):571-4. PubMed ID: 2737264.
    Abstract:
    It was found that a decrease in electrophoretic mobility of pyruvate kinase (PK) isoenzyme, and an increase of the sensitivity of this enzyme to L-cysteine, were markers of immortalization and tumorigenic properties, respectively, in human urothelial cell lines characterized by different grades of transformation (TGr) in vitro.
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