These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antimalarial Phenanthroindolizine Alkaloids from Ficus septica.
    Author: Kubo M, Yatsuzuka W, Matsushima S, Harada K, Inoue Y, Miyamoto H, Matsumoto M, Fukuyama Y.
    Journal: Chem Pharm Bull (Tokyo); 2016; 64(7):957-60. PubMed ID: 27373653.
    Abstract:
    During the screening of antimalarial substances, MeOH extract from the twigs of Ficus septica was shown to have potent antimalarial activity. Bioassay-guided fractionation of a methanol extract of the twigs of F. septica led to the isolation of a new seco-phenanthroindolizine alkaloid and three known phenanthroindolizine alkaloids. Their structures were elucidated on the basis of NMR analysis. All isolated compounds were tested against Plasmodium falciparum. Compounds 2-4 displayed antimalarial activity against the 3D7 strain of P. falciparum with IC50 values 0.028-0.42 µM, whereas a new compound 1 exhibited a moderate antimalarial activity.
    [Abstract] [Full Text] [Related] [New Search]