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  • Title: Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus.
    Author: Livingston JH, Brown JK, Harkness RA, McCreanor GM.
    Journal: Dev Med Child Neurol; 1989 Apr; 31(2):168-73. PubMed ID: 2737369.
    Abstract:
    The authors studied specific and sensitive indicators of neuronal adenosine triphosphate (ATP) depletion--hypoxanthine, xanthine and uridine levels--in the cerebrospinal fluid (CSF) of nine children during non-convulsive status epilepticus. No evidence of ATP depletion was found and CSF pH and creatine kinase levels were similar to those of controls. Hypoxanthine, xanthine and uridine had a tendency to be low, but this was significant only for xanthine. The authors speculatively link this reduction to a reduction in neuronal protein synthesis. This might be a mechanism whereby non-convulsive status epilepticus could lead to intellectual deterioration and dementia.
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