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  • Title: [Change in tryptophan hydroxylase activity in the brain of silver foxes and wild Norway rats in the course of selection according to behavior].
    Author: Kulikov AV, Zhanaeva EIu, Popova NK.
    Journal: Genetika; 1989 Feb; 25(2):346-50. PubMed ID: 2737466.
    Abstract:
    The activity of tryptophan hydroxylase, the key enzyme of serotonin biosynthesis, was determined in the brain of silver foxes and wild rats selected, according to domestic or aggressive behavior, in respect to man. Significant increase of enzyme activity in midbrain of both domesticated rats and domesticated foxes was found, in comparison with that of aggressive animals. It was suggested that genetic mechanisms of the selection according to aggressive behavior, involve the changes of genes responsible for the synthesis of serotonin, the brain neurotransmitter which inhibits this type of behavior.
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