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  • Title: Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX.
    Author: Lyu Y, Chen G, Shangguan D, Zhang L, Wan S, Wu Y, Zhang H, Duan L, Liu C, You M, Wang J, Tan W.
    Journal: Theranostics; 2016; 6(9):1440-52. PubMed ID: 27375791.
    Abstract:
    Detecting and understanding changes in cell conditions on the molecular level is of great importance for the accurate diagnosis and timely therapy of diseases. Cell-based SELEX (Systematic Evolution of Ligands by EXponential enrichment), a foundational technology used to generate highly-specific, cell-targeting aptamers, has been increasingly employed in studies of molecular medicine, including biomarker discovery and early diagnosis/targeting therapy of cancer. In this review, we begin with a mechanical description of the cell-SELEX process, covering aptamer selection, identification and identification, and aptamer characterization; following this introduction is a comprehensive discussion of the potential for aptamers as targeting moieties in the construction of various nanotheranostics. Challenges and prospects for cell-SELEX and aptamer-based nanotheranostic are also discussed.
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