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  • Title: Effect of antihypertensive therapy on plasma lipids and lipoproteins in mild hypertension.
    Author: Sagar S, Majumdar S, Sharma BK.
    Journal: Indian Heart J; 1989; 41(1):39-50. PubMed ID: 2737688.
    Abstract:
    Antihypertensive drugs have been incriminated for altering the lipid profile of hypertensives, obscuring the beneficial effect of blood pressure reduction on coronary artery disease. The effects of Propranolol, Nifedipine and Hydrochlorothiazide on plasma lipid fractions in recently diagnosed mild hypertensives, randomly allocated to PROP, NIF, HCT groups were studied at 0, 12 and 24 weeks of treatment. Target DBP of less than or equal to 90 mmHg was achieved in all the groups of patients. At 24 weeks, skewed distribution of lipid components was observed in PROP and NIF groups without significant alteration in various lipid fractions. In HCT group, TG increased and HDL-C and HDL-C/CH decreased significantly. Long-term significance of these changes, which make the lipid profile more atherogenic, needs to be considered while treating hypertensives.
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