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  • Title: Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences.
    Author: Vartdal F, Sollid LM, Vandvik B, Markussen G, Thorsby E.
    Journal: Hum Immunol; 1989 Jun; 25(2):103-10. PubMed ID: 2737928.
    Abstract:
    Of 61 Norwegian multiple sclerosis patients tested, 59, i.e., 97%, were positive for at least one of the HLA specificities DR2, DR4, or DRw6. Typing with sequence-specific oligonucleotide probes revealed that the same 59 patients carried DR2-, DR4-, or DRw6-associated HLA-DQB1 genes which encode shared polymorphic amino acid sequences in the membrane-distal part of their HLA-DQ beta chains. This shared DQ beta polymorphism may explain previously reported DR associations and could thus be the primary HLA association in MS.
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