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  • Title: Changes in cochlear microphonic and neural sensitivity produced by acoustic trauma.
    Author: Patuzzi RB, Yates GK, Johnstone BM.
    Journal: Hear Res; 1989 May; 39(1-2):189-202. PubMed ID: 2737965.
    Abstract:
    The low-frequency (200 Hz) microphonic potentials at the round window and in the organ of Corti of the first turn of the guinea pig cochlea have been measured before and after acoustic overstimulation. Reductions in the amplitude of this microphonic after loud sound are highly correlated with neural threshold elevation in this region. The fall in the microphonic amplitude appears due to an inactivation of mechano-electrical transduction channels at the apex of the outer hair cells into a closed state. These results are consistent with the idea that the current through the outer hair cells controls the mechanical sensitivity of the organ of Corti, and that the temporary loss of mechanical and neural sensitivity following loud sound is due to a simple inactivation of the mechano-electrical transduction channels.
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