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  • Title: [Hemophilia B replacement therapy drugs].
    Author: Yan H, Zeng F.
    Journal: Sheng Wu Gong Cheng Xue Bao; 2016 Feb; 32(2):164-71. PubMed ID: 27382766.
    Abstract:
    Hemophilia B is an X chromosome linked hereditary hemorrhagic disease, which is caused by the lose function mutation of factor IX (FIX), and significantly affects the patients' lifespan and life quality. The severity of hemophilia B depends on the FIX level in the plasma. By referring to the relevant literatures, we reviewed and summarized hemophilia B replacement therapies. Specifically, we focus on recombinant factor IX products on the market and those in the pipeline, especially on the long-acting factor IX drugs, to provide the basis for researches of new hemophilia B drugs.
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