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  • Title: Sublingual buprenorphine and pethidine for immediate postoperative pain relief in major gynecologic surgery: a comparative study.
    Author: Tungphaisal S, Chandeying V, Sutthijumroon S, Aeuwpadung S.
    Journal: J Med Assoc Thai; 1989 Mar; 72(3):150-3. PubMed ID: 2738496.
    Abstract:
    The analgesic effect of sublingual buprenorphine 0.4 mg has been compared with pethidine 1 mg/kg given intramuscularly in 80 patients following major gynecologic operation. The results indicate a slower onset of action for sublingual buprenorphine in the first two hours (p less than 0.001), but it has a much longer duration and is more effective for pain relief (p less than 0.001) than pethidine. The main side-effects were nausea and vomiting which occurred after both treatments but with no significant difference.
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