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  • Title: Comparative effects of roxithromycin and erythromycin on cellular immune functions in vitro. 2. Chemotaxis and phagocytosis of 3H-Staphylococcus aureus by human macrophages.
    Author: Carlone NA, Cufini AM, Tullio V, Sassella D.
    Journal: Microbios; 1989; 58(234):17-25. PubMed ID: 2739586.
    Abstract:
    The in vitro effects of roxithromycin on human macrophage activity were compared with those of erythromycin. Half the MIC of roxithromycin significantly enhanced the phagocytosis of 3H-labelled Staphylococcus aureus by human macrophages. Bacterial phagocytosis was also increased after pre-incubation of staphylococci with roxithromycin. Erythromycin displayed a less stimulating effect. Pre-incubation of macrophages with the drugs caused a depression of staphylococcal uptake by phagocytes. Macrophage chemotaxis was unchanged in the presence of both macrolides.
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