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  • Title: Evaluation of the local antihistaminic activity of dimetindene maleate by a quantitative method.
    Author: Rampini E, Oberhauser V, Nunzi E.
    Journal: Dermatologica; 1978; 157(2):105-9. PubMed ID: 27397.
    Abstract:
    The topical application of a 0.1% dimetindene maleate gel on the forearms of 11 subjects reduces the areas of both erythema and wheal produced by the intradermal injection of 0.025 mg of histamine hydrochloride to a statistically greater degree than 1% d-chlorpheniramine maleate cream (p less than 0.005 and p less than 0.0005, respectively). The quantitative method employed in this study has proved to be an excellent means for the evaluation of the antihistaminic activity of topical preparations.
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