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  • Title: Dissociation of AIDS-related vacuolar myelopathy and productive HIV-1 infection of the spinal cord.
    Author: Rosenblum M, Scheck AC, Cronin K, Brew BJ, Khan A, Paul M, Price RW.
    Journal: Neurology; 1989 Jul; 39(7):892-6. PubMed ID: 2739916.
    Abstract:
    Although merging clinically within the spectrum of the AIDS dementia complex, vacuolar myelopathy is a pathologically distinct entity detected in up to 30% of autopsied patients succumbing to the late complications of human immunodeficiency virus type 1 (HIV-1) infection. Using immunohistochemistry and in situ hybridization to detect an HIV-1 core protein and viral mRNA, respectively, in tissue sections, and culture isolation to assess infectious virus in tissue homogenates, we found that vacuolar myelopathy was independent of productive HIV-1 infection of the spinal cord and brain. These results indicate that AIDS-associated vacuolar myelopathy is either not related directly to spinal cord HIV-1 infection or involves nonproductive infection and pathobiological processes distinct from those responsible for the multinucleated-cell inflammatory infiltrates that serve as histopathologic markers of productive CNS HIV-1 infection.
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