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  • Title: Value of bilateral iliac crest needle biopsy for pretherapeutic tumor staging of bronchogenic carcinomas.
    Author: Manegold C, Krempien B, Bülzebruck H, Drings P.
    Journal: Oncology; 1989; 46(4):226-9. PubMed ID: 2740064.
    Abstract:
    Two hundred and forty-three patients with lung cancer were biopsied pretherapeutically and bilaterally on the anterior iliac crest. Tumor infiltration into the bone marrow could be demonstrated in 7 patients. No tumor-positive biopsies were found in the 163 patients with non-small cell lung cancer (NSCLC). In small cell lung cancer (SCLC), however, the infiltration rate was 9% (7/80). In 3 of the 7 patients (43%) only 1 of the 2 sides biopsied had been infiltrated. All 7 patients with tumor-positive bone marrow samples were found to have additional metastases elsewhere (stage IV, 7/26; 27%). Therefore, according to our results, we cannot recommend iliac crest biopsy as a routine pretherapeutic procedure to aid in the staging of SCLC and NSCLC.
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