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  • Title: [An unusual mechanism of lead poisoning. Presentation of a case].
    Author: D'Alessandro Gandolfo L, Macrì A, Biolcati G, Rossi F, Cirelli A, Barlattani A, Topi GC.
    Journal: Recenti Prog Med; 1989 Mar; 80(3):140-1. PubMed ID: 2740602.
    Abstract:
    A case is described, that came to our attention for suspected acute intermittent porphyria, with abdominal pain and ascending tetraplegia. The patient (HIV positive and with a HBsAg positive chronic aggressive hepatitis) was a heroin addict. In urine: high porphyrins with extremely increased delta amino-levulinic acid (ALA) and normal porphobilinogen. High protoporphyrin was present in blood red cells. The lead poisoning was confirmed by a very low ALA-dehydratase activity in erythrocytes and a high content of lead in urine and plasma. With Ca-versenate and penicillamine the abdominal and neurological symptoms rapidly disappeared. The possibility of contact with lead, professional or environmental, was ruled out. It was found however, that shortly before the appearance of symptoms, the patient had used a batch of unrefined brown sugar heroin, which was probably mixed with lead salts. It is noteworthy that during the same period, other young heroin addicts died with similar symptoms.
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