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  • Title: A case of TAFRO syndrome, a variant of multicentric Castleman's disease, successfully treated with corticosteroid and cyclosporine A.
    Author: Takasawa N, Sekiguchi Y, Takahashi T, Muryoi A, Satoh J, Sasaki T.
    Journal: Mod Rheumatol; 2019 Jan; 29(1):198-202. PubMed ID: 27413814.
    Abstract:
    We report a case of a 46-year-old woman with fever, pleural effusion, massive ascites, severe edema, hepatosplenomegaly, elevation of serum creatinine level, proteinuria, and severe thrombocytopenia. Her clinical features were compatible with TAFRO syndrome proposed as a variant of multicentric Castleman's disease, that is occasionally associated with poor prognosis. Treatment with corticosteroid improved her symptoms partially. However, thrombocytopenia, ascites, and edema persisted. The use of cyclosporine A successfully improved her condition, resulting in remission.
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