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  • Title: [Substances with antibacterial and antifungal activity. VI. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole and 1,4-pyrrolphenylene].
    Author: Porretta GC, Cerreto F, Fioravanti F, Biava M, Scalzo M, Fischetti M, Riccardi F.
    Journal: Farmaco; 1989 Jan; 44(1):51-63. PubMed ID: 2742721.
    Abstract:
    New 1,5-diarylpyrrole and 1,4-pyrrolphenylene derivatives were prepared to study influence on the microbiological activity of an unsubstituted pyrrole nucleus or of a double identical molecular structure. Antimicrobial data in comparision with antifungal antibiotic pyrrolnitrin showed that all tested compounds exhibited very poor antifungal and antibacterial activity. Only some derivatives showed a selective activity against strains of Candida sp. and against strains of gram-positive or gram-negative bacteria.
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