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  • Title: [Substances with antibacterial and antifungal activity. VII. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole].
    Author: Porretta GC, Cerreto F, Fioravanti R, Biava M, Scalzo M, Simonetti N, D'Auria FD.
    Journal: Farmaco; 1989 Jan; 44(1):65-76. PubMed ID: 2742722.
    Abstract:
    The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. Antimicrobial data in comparison with pyrrolnitrin show that N-methylpiperazinylamides exhibit very poor activity against Candida albicans and Candida sp. while acid and ester derivatives are inactive. Vice-versa many acid or amide derivatives show interesting antibacterial activity. The results obtained are discussed on the basis of structure-activity relationships.
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