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  • Title: Monoamine oxidase inhibitors from Cinchonae Cortex.
    Author: Mitsui N, Noro T, Kuroyanagi M, Miyase T, Umehara K, Ueno A.
    Journal: Chem Pharm Bull (Tokyo); 1989 Feb; 37(2):363-6. PubMed ID: 2743481.
    Abstract:
    Three strong alkaloidal monoamine oxidase (MAO) inhibitors, quinine (1), cinchonicinol ([ 1S,3'R,4'R]-3-(3-ethenyl-4-piperidinyl)-1-(4-quinolinyl)-1-propanol) (2) and cinchonaminone ([ 3'R,4'S]-2-[2-(3-ethenyl-4-piperidinyl)-acetyl]-1H-indole-3-ethanol) (3), were isolated from Cinchonae Cortex (Cinchona succirubra Pav., Rubiaceae). The structures of 2 and 3 were elucidated on the bases of spectral data and chemical evidence, and 3 is a new alkaloid. The inhibitory effects on MAO of 1, 2, 3 and related alkaloids were assayed. The type of inhibition by 1 with respect to benzylamine as a substrate was competitive.
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