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  • Title: Haarlem 3 is the predominant genotype family in multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis in the capital of Iran: A 5-year survey.
    Author: Khanipour S, Ebrahimzadeh N, Masoumi M, Sakhaei F, Alinezhad F, Safarpour E, Fateh A, Nour Nematollahi A, Hadizadeh Tasbiti A, Zolfaghari MR, Bahrmand AR, Mirsaeidi M, Rahimi Jamnani F, Vaziri F, Siadat SD.
    Journal: J Glob Antimicrob Resist; 2016 Jun; 5():7-10. PubMed ID: 27436458.
    Abstract:
    The objective of this study was to further understand the genetic diversity of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis isolates prevalent in Tehran, the capital city of Iran. From January 2010 to March 2015, a total of 723 M. tuberculosis strains were isolated from patients with pulmonary tuberculosis (TB). A total of 23 MDR, pre-XDR and XDR M. tuberculosis isolates were genotyped by spoligotyping and 24-loci mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR) typing. The results showed that the MDR, pre-XDR and XDR M. tuberculosis strains mainly belonged to the Haarlem 3 genotype (11/23; 47.8%), followed by the Beijing family (9/23; 39.1%). In addition, the 23 strains were clustered into 21 genotypes using a 24-loci MIRU-VNTR. In conclusion, Haarlem 3 genotype was the predominant genotype among the isolates from MDR-TB cases in this study, which could be of special concern.
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