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  • Title: Clinical evaluation of imipenem/cilastatin in the therapy of severe infections in high-risk patients.
    Author: Cristiano P.
    Journal: Drugs Exp Clin Res; 1989; 15(1):17-20. PubMed ID: 2743870.
    Abstract:
    A clinical trial was carried out to evaluate the effectiveness of treatment with imipenem/cilastatin in life-threatening infections in high-risk patients. Thirty hospitalized patients (22 men and 8 women), aged 28 to 78 years, with impaired host defences and severe infections were treated with imipenem/cilastatin at a dosage ranging between 1 and 3 g daily i.v. at 8 or 12 h intervals. The average length of therapy was 8.61 +/- 3.14 days. The isolated organisms were as follows: Escherichia coli [7], Pseudomonas aeruginosa [9], Staphylococcus aureus [5], Streptococcus faecalis [3], Strep. viridans [1], Proteus mirabilis [1], P. vulgaris [2], Klebsiella pneumoniae [2], Citrobacter freundii [2], Bacteroides fragilis [2]. In only one patient the aetiological agent remained unknown and in five patients (16.67%) a mixed infection was observed. Twenty-four patients (80%) were completely cured of infection and 29 isolated organisms (82.86%) were eradicated. No important side-effects were observed.
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