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  • Title: Gingival granulomatosis with polyangiitis (Wegener's granulomatosis) as a primary manifestation of the disease.
    Author: Fonseca FP, Benites BM, Ferrari A, Sachetto Z, de Campos GV, de Almeida OP, Fregnani ER.
    Journal: Aust Dent J; 2017 Mar; 62(1):102-106. PubMed ID: 27439744.
    Abstract:
    Granulomatosis with polyangiitis (GPA) is a potentially lethal disease characterized by systemic necrotizing vasculitis, which affects small- and medium-sized blood vessels and is often associated with serum cytoplasmic antineutrophil cytoplasmic antibody. The upper and lower respiratory tract and kidney are the most involved sites, but oral lesions can be identified in 6-13% of the cases, whereas in only 2% of the cases, oral manifestations represent the first signal of the disease usually as gingival swellings or unspecific ulcerations. Without treatment, the mainstay of which is the combination of immunosuppressants and systemic corticosteroids, GPA may run a fatal course. In this report we describe an original case of GPA affecting a 75-year-old female patient referred to our service due to a gingival swelling with 3-month duration. Although the patient was correctly diagnosed and promptly treated, she died 3 months after the initial diagnosis.
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