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  • Title: [Comparative study of the effect of the thymus preparations thymoptin and thymalin on fibrin-monomer polymerization].
    Author: Pastorova VE, Liapina LA, Ashmarin IP, Kudriashov BA, Zazhireĭ VD.
    Journal: Farmakol Toksikol; 1989; 52(2):47-50. PubMed ID: 2744143.
    Abstract:
    Thymoptin was shown to possess the ability of lysis of the nonstabilized fibrin in vitro and of increasing the nonenzymatic fibrinolytic activity of blood plasma after eight daily intramuscular injections to rats in doses of 1 and 100 micrograms/kg body weight and during incubation with purified fibrin monomer to produce its depolymerization. Thymalin possessed no nonenzymatic fibrinolytic activity in vitro and in contrast to thymoptin at a relatively high concentration (1000 and 100 micrograms/ml) enhanced fibrin-monomer polymerization.
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