These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review.
    Author: Bartel MJ, Seeger K, Jeffers K, Clayton D, Wallace MB, Raimondo M, Woodward TA.
    Journal: Dig Liver Dis; 2016 Sep; 48(9):1058-65. PubMed ID: 27443493.
    Abstract:
    BACKGROUND: Recurrent complex esophageal strictures remain difficult to manage. AIMS: To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures. METHODS: All patients who underwent balloon dilation followed by topical Mitomycin C application for recurrent benign esophageal strictures were included. Primary outcome was number of dilations and change of dysphagia score. RESULTS: Nine patients with anastomotic (3), radiation-induced (3), caustic (2), and combined anastomotic and radiation-induced (1) strictures were included. Strictures had a mean length of 13.75mm, diameter of 8.0mm, and were dilated 10.7 times over a median of 8 months (1.5 dilations per month). Following Mitomycin C application, the need for further dilation decreased to 0.39 dilations per month over a median of 10 months; however, dysphagia scores improved not significantly from 3.2 to 2.6 (mean). CONCLUSION: In this pilot study, topical Mitomycin C in conjunction with dilation decreased the frequency of esophageal dilations for recurrent benign esophageal strictures.
    [Abstract] [Full Text] [Related] [New Search]