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  • Title: Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker.
    Author: Earlam K, Souza CA, Glikstein R, Gomes MM, Pakhalé S.
    Journal: Can Respir J; 2016; 2016():3740902. PubMed ID: 27445532.
    Abstract:
    Langerhans cell histiocytosis is characterized by the abnormal nodular proliferation of histiocytes in various organ systems. Pulmonary involvement seen in young adults is nearly always seen in the context of past or current cigarette smoking. Although it tends to be a single-system disease, extrapulmonary manifestations involving the skin, bone, and hypothalamic-pituitary-axis are possible. High resolution CT (HRCT) of the thorax findings includes centrilobular nodules and cysts that are bizarre in shape, variable in size, and thin-walled. Often the diagnosis can be made based on the appropriate clinical presentation and typical imaging findings. Treatment includes smoking cessation and the potential use of glucocorticoids or cytotoxic agents depending on the severity of disease and multisystem involvement.
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