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  • Title: Non-invasive assessment of left ventricular performance in patients with coronary artery disease after chronic diltiazem therapy.
    Author: Cinquegrana G, Spinelli L, Ferro G, Cristiano C, Spadafora M, Ferrara M.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1989 Jan; 27(1):27-9. PubMed ID: 2744903.
    Abstract:
    To evaluate the effects of diltiazem (240 mg/day) on the left ventricular function, we studied 13 patients with coronary artery disease (CAD). Comparison with placebo was made in a double-blind randomized crossover study. Both placebo and diltiazem were administered for 5 weeks. We assumed left ventricular systolic time intervals assessed by polycardiography as parameter of ventricular function. Diltiazem induced a significant decrease in pre-ejection period (p less than 0.01) as well as pre-ejection period/left ventricular ejection time ratio (p less than 0.01). Thus, our results suggest that diltiazem improves the contractile state of ischemic myocardium in CAD patients.
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