These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs].
    Author: Ma Q, Wang L, Yao H, Zhu J, Wang S, Zhang X, Wang T, Ma Y, Su Y, Wang Z, Ding L.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2016 Aug; 33(4):540-4. PubMed ID: 27455017.
    Abstract:
    OBJECTIVE: To assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China. METHODS: One thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system. RESULTS: The distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups (P>0.05). After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model (OR=1.181, 95%CI: 1.021-1.366, P=0.025; OR=1.296, 95%CI: 1.043-1.610, P=0.019). The total cholesterol level was higher in AA carriers than GG and GA carriers (P<0.05). CONCLUSION: The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.
    [Abstract] [Full Text] [Related] [New Search]