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  • Title: Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.
    Author: Dong Y, Wang W, Veiseh O, Appel EA, Xue K, Webber MJ, Tang BC, Yang XW, Weir GC, Langer R, Anderson DG.
    Journal: Langmuir; 2016 Aug 30; 32(34):8743-7. PubMed ID: 27455412.
    Abstract:
    Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid-glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10-60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.
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