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  • Title: Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer.
    Author: Zhang Y, Wen X, Hu XL, Cheng LZ, Yu JY, Wei ZB.
    Journal: Eur Rev Med Pharmacol Sci; 2016 Jul; 20(14):3026-30. PubMed ID: 27460730.
    Abstract:
    OBJECTIVE: The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC). PATIENTS AND METHODS: Expression of miR-145-5p was evaluated by qRT- PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopathological parameters was investigated. Finally, the survival was assessed by the Kaplan-Meier method and proportional hazards model. RESULTS: Expression levels of miR-145-5p in GC tissues were significantly lower than those in adjacent normal tissues (p < 0.001). MiR-145-5p expression was significantly associated with lymph node metastasis, metastasis stage, and distant metastasis (all p < 0.05). Furthermore, Patients with low miR-145-5p expression had poorer overall survival time than those with high miR-145-5p expression (p = 0.014). Moreover, univariate and multivariate Cox analysis showed that miR-145-5p was an independent prognostic indicator for OS (p = 0.011). CONCLUSIONS: MiR-145-5p is down-expressed in GC, and can be used as a marker of poor prognosis in GC patients.
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